Transcriptional Enhancers in Drosophila
نویسندگان
چکیده
منابع مشابه
DETECTION OF GENE ENHANCERS BY Drosophila ENHANCER TRAP ANALYSIS Enhancers: Transcriptional enhancers are DNA sequences
Enhancers: Transcriptional enhancers are DNA sequences that control expression of nearby genes and direct tissue-specific, positive regulation of those genes (Karp, 2002; Griffiths, et al., 2002). The general mode of action of these sequences is that they associate with specific activator proteins (that are found in only certain tissues); this association of enhancer and activator facilitates t...
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One of the key issues in studying transcriptional regulation during development is how to employ genome-wide assays that reveals sites of open chromatin and transcription factor binding to efficiently identify biologically relevant genes and enhancers. Analysis of Drosophila CNS midline cell development provides a useful system for studying transcriptional regulation at the genomic level due to...
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Transcriptional enhancers integrate positional and temporal information to regulate the complex expression of developmentally controlled genes. Current models suggest that enhancers act as computational devices, receiving multiple inputs from activators and repressors and resolving them into a single positive or a negative signal that is transmitted to the basal transcriptional machinery. We sh...
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Regulatory DNAs serve as templates to bring weakly interacting transcription factors into close proximity so they can work synergistically to switch genes on and off in time and space. Most of these regulatory DNAs are enhancers that can work over long distances--a million base pairs or more in mammals--to control gene expression. Critical enhancers are sometimes even found within the introns o...
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In higher eukaryotes, transcriptional enhancers play critical roles in the integration of cellular signaling information, but apart from a few well-studied model enhancers, we lack a general picture of transcriptional information processing by most enhancers. Here we discuss recent studies that have provided fresh insights on information processing that occurs on enhancers, and propose that in ...
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ژورنال
عنوان ژورنال: Genetics
سال: 2020
ISSN: 1943-2631
DOI: 10.1534/genetics.120.301370